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What is Science Based Fitness?

Your free- source of information, news, and deep dive into the latest science in the world or fitness and health. We dive deep into the literature and debunk a lot of fake claims. Also, providing helpful tips and workouts to improve your health and quality of life. 

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The benefits of

Berberine

Berberine Benefits

Berberine is a plant alkaloid possessing scientifically determined mechanisms of the prevention of the development of atherosclerosis, type 2 diabetes, and obesity, as well as cardiovascular complications and cancer.

Should You take Berberine?

    Recently, a lot of claims have been made regarding the benefits of Berberine. Such claims are comparing Berberine to a popular weight loss drug, Ozempic. However, more research has shown the protective benefits of Berberine including prevention of cardiovascular disease and cancer. In addition to prevention, the benefits of Berberine have shown positive results for metabolic syndrome and diabetes. A recent study has confirmed the significance of its anticancer activity and its effectiveness in neurological, metabolic, and cardiovascular disorders. The compound has been subjected to multiple clinical evaluations in patients with the metabolic syndrome, and its use in related diseases

The fight between metabolic syndrome and insulin resistance! It’s important to focus on obesity and insulin resistance, which is a major component of obesity. Berberine may also help your body utilize glucose more effectively, which is a major problem with prediabetic patients. Berberine also enhances the expression of the AMPK-dependent adipose tissue triglyceride lipase, which is positively associated with long-term weight loss and is one of the mechanisms of action in the prevention of obesity. 

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Benefits of Berberine

The primary benefits of Berberine is weight loss by improving glucose metabolism. Berberine has always been used in traditional medicine as a plant extract, but new research methods have established that berberine is a promising treatment for current diseases. A recent study has confirmed the significance of its anticancer activity and its effectiveness in neurological, metabolic, and cardiovascular disorders. 

  • Potential Weight loss
  • Antidiabetic Protection
  • Cholesterol Lowering Effect
  • Improved Gut Microbiota
  • Anti-inflammatory
  • Anti-cancer
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Sources

Och A, Och M, Nowak R, Podgórska D, Podgórski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022 Feb 17;27(4):1351. doi: 10.3390/molecules27041351. PMID: 35209140; PMCID: PMC8874997.

Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, Chen Q. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. doi: 10.3389/fphar.2021.653887. PMID: 33981233; PMCID: PMC8107691.

Lee B, Shim I, Lee H, Hahm DH. Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder. Korean J Physiol Pharmacol. 2018 Mar;22(2):183-192. doi: 10.4196/kjpp.2018.22.2.183. Epub 2018 Feb 23. PMID: 29520171; PMCID: PMC5840077.

Shrinivas K. Kulkarni, Ashish Dhir,
On the mechanism of antidepressant-like action of berberine chloride,
European Journal of Pharmacology,
Volume 589, Issues 1–3, 2008, Pages 163-172, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2008.05.043.

Fan J, Zhang K, Jin Y, Li B, Gao S, Zhu J, Cui R. Pharmacological effects of berberine on mood disorders. J Cell Mol Med. 2019 Jan;23(1):21-28. doi: 10.1111/jcmm.13930. Epub 2018 Nov 18. PMID: 30450823; PMCID: PMC6307759.

Fang W, Huang X, Wu K, Zong Y, Yu J, Xu H, Shi J, Wei J, Zhou X, Jiang C. Activation of the GABA-alpha receptor by berberine rescues retinal ganglion cells to attenuate experimental diabetic retinopathy. Front Mol Neurosci. 2022 Aug 9;15:930599. doi: 10.3389/fnmol.2022.930599. PMID: 36017075; PMCID: PMC9396352.

Lu Yang, Yuzhen Huang, Fengxi Chen, Yan Wang, Kunhan Su, Ming Zhao, Weiwei Tao, Wanli Liu,
Berberine attenuates depression-like behavior by modulating the hippocampal NLRP3 ubiquitination signaling pathway through Trim65,
International Immunopharmacology,
Volume 123, 2023, 110808, ISSN 1567-5769,
https://doi.org/10.1016/j.intimp.2023.110808.