Science Based Fitness

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What is Science Based Fitness?

Your free- source of information, news, and deep dive into the latest science in the world or fitness and health. We dive deep into the literature and debunk a lot of fake claims. Also, providing helpful tips and workouts to improve your health and quality of life. 

Best Way To Build Muscle

HOw to Train
Like a
Pro

ultimate personal training

About Nate

hello I'm Nate

Natural PNBA Pro: I’ve been training for over 15 years, and I’m always learning, adapting, and growing. Follow me on my journey as I get on the stage for a lifetime natural competition. 

Together, we’ll grow and get stronger. 

Dedication
100%
Cardio
10%
nutrition
60%
body building
30%

Progressive Overload

Gradually increase the weight, reps, or intensity over time to challenge your muscles. Aim to improve weekly or biweekly, but avoid plateaus by varying stimuli.

Rep Range

Focus on 6–12 reps per set for most exercises, as this range is optimal for hypertrophy. Occasionally include lower reps (3–6) for strength or higher reps (12–20) for endurance and metabolic stress.

Time Under Tension

Lift with controlled tempo (e.g., 2–3 seconds lowering, 1–2 seconds lifting) to maximize muscle fiber activation. Avoid rushing reps.

Mind - Muscle Connection is crucial

Power lifters try to move as much weight as they can using all the muscle they can. They sacrifice form for movement, which is fine if you want to be a power lifter.

Body Builders try to move the lighter weight focusing on one muscle making it as difficult as they can.  

The key is being able to choose a weight you can move for 10-12 reps with great form while squeezing the muscle and moving slowly. 

Supplements

Supplements backed by science to help build muscle 

Training Principles for Hypertrophy

Nothing Feels As Good As Being Fit

Progressive Overload: Gradually increase the weight, reps, or intensity over time to challenge your muscles. Aim to improve weekly or biweekly, but avoid plateaus by varying stimuli.
 
Rep Range: Focus on 6–12 reps per set for most exercises, as this range is optimal for hypertrophy. Occasionally include lower reps (3–6) for strength or higher reps (12–20) for endurance and metabolic stress.
 
Volume: Perform 10–20 sets per muscle group per week, spread across 2–4 sessions. For example, 3–5 sets per exercise, targeting each muscle group 2–3 times weekly.
 
Time Under Tension: Lift with controlled tempo (e.g., 2–3 seconds lowering, 1–2 seconds lifting) to maximize muscle fiber activation. Avoid rushing reps.
 
Exercise Selection: Use a mix of compound lifts (e.g., squats, deadlifts, bench press, pull-ups) and isolation exercises (e.g., bicep curls, leg extensions) to target all muscle groups
 
Rest Between Sets: Rest 60–90 seconds for smaller muscle groups (e.g., arms) and 2–3 minutes for larger groups (e.g., legs, back) to allow partial recovery while maintaining intensity.

tracking

Rep ranges and weights

nutrition

Calories, Proteins, Carbs, and Fats

Fat burning

Fat burning technique trining

personal ESSENCIAL TRAINING

Overview & goals

To maximize muscle growth (hypertrophy) through weight lifting, you need to focus on a combination of proper training techniques, progressive overload, nutrition, recovery, and consistency. Below is a concise, evidence-based guide to optimize your weightlifting approach
Eat slightly more calories (10–15% above maintenance) to fuel muscle growth. Use a calorie calculator to estimate needs.
 
Consume 1.6–2.2 g of protein per kg of body weight daily (e.g., 120–160 g for a 75 kg person). Spread intake across 3–5 meals.
 
Carbs fuel performance (4–7 g/kg body weight), while fats support hormones (0.5–1 g/kg). Prioritize complex carbs (e.g., rice, oats) and healthy fats (e.g., avocado, nuts).
 
Eat a protein-rich meal 2–3 hours before and after training. A post-workout shake with 20–40 g protein can help, but whole foods work too.

Recent Articles

Science Based Articles 

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Secrets to Anti Aging

s we age, we have a higher risk of neurocognitive disorders. Diet, lifestyle, and genetics are the primary factors for age-related diseases. However, there are many things we can do to limit our risk. The data doesn’t support the notion that we’re able to reverse or deny aging. However, we can take extra steps to maintain great health and limit our risk.

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Fad Diet Failures

A fad diet is a trendy, often highly restrictive eating plan promoted as a quick solution for weight loss or health improvement, typically lacking scientific evidence or long-term sustainability.

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Why you should take creatine

Creatine has been proven to be a valuable supplement when it comes to increasing muscle and recovery, but new research may conclude possible cognitive benefits

nmn

NMN

The secret to reduce aging and improve quality of life.

New articles every week
To maximize muscle growth (hypertrophy) through weight lifting, you need to focus on a combination of proper training techniques, progressive overload, nutrition, recovery, and consistency.

Fad Diets

Fad diets and health trends

Why diets fail

Fad diets and failures

Overview & facts

A fad diet is a trendy, often highly restrictive eating plan promoted as a quick solution for weight loss or health improvement, typically lacking scientific evidence or long-term sustainability.
 
These diets often emphasize specific foods, extreme calorie cuts, or the elimination of entire food groups (e.g., keto, paleo, grapefruit diet, or juice cleanses) while promising rapid results. They may lead to short-term weight loss due to calorie restriction but often fail to provide balanced nutrition, can cause nutrient deficiencies, and are difficult to maintain, leading to weight regain.
 

Carbs make you fat myth

Carbs Make You Gain Weight

Carbohydrates don’t inherently cause weight gain. Excess calories from any source—carbs, fats, or proteins—lead to weight gain. Whole carbs like oats, quinoa, and vegetables provide fiber, nutrients, and sustained energy. The key is portion control and choosing complex carbs over refined ones.

Trying to sell you something

Trendy typically means there's a volumes of services or social media following

Trend diets, or fad diets, are often driven by profit motives, capitalizing on public desire for quick weight loss or health fixes. These diets—think keto, paleo, intermittent fasting, or detox cleanses—generate revenue through various channels. Books, meal plans, supplements, and branded products

Supplement Sales

rapid body transformations

The global weight loss industry, including fad diets, is worth over $250 billion annually, with supplements alone generating billions. Companies exploit emotional triggers, like body image concerns, to sell high-margin products, despite many lacking scientific backing or long-term efficacy.
Fad diets tend to oversimplify complex health needs, rely on anecdotal success stories, and may not address lifestyle factors like exercise or mental health. For sustainable weight management, evidence-based approaches focusing on balanced, whole-food diets and gradual changes are recommended. Always consult a healthcare professional before starting any diet.
Diet Trend Myths
Trend diets, or fad diets, are often driven by profit motives, capitalizing on public desire for quick weight loss or health fixes. These diets—think keto, paleo, intermittent fasting, or detox cleanses—generate revenue through various channels. Books, meal plans, supplements, and branded products (e.g., keto snacks, cleanse juices) are heavily marketed, often endorsed by celebrities or influencers on platforms like X, promising rapid results. The global weight loss industry, including fad diets, is worth over $250 billion annually, with supplements alone generating billions. Companies exploit emotional triggers, like body image concerns, to sell high-margin products, despite many lacking scientific backing or long-term efficacy. For example, detox teas or "fat-burning" pills often rely on laxatives or caffeine, offering temporary effects at best. Meanwhile, unsustainable diets lead to weight regain, creating a cycle where consumers repeatedly buy new solutions. Ethical concerns arise when companies prioritize profit over health, promoting restrictive plans that may cause nutrient deficiencies or disordered eating. For sustainable health, evidence-based, balanced diets outperform profit-driven trends. Always consult a dietitian before trying any diet.

Shilajit

Shilajit

Increase energy, testosterone, and strength, or just a myth? 

Shilajit

True or false?

Also known as Salajit, shilajatu, mimie, or mummiyo, and it’s a black-like powder gathered from the high mountain rocks from the Himalayans. Origins have been also discovered in Russia, Tibet, Afghanistan, and Chile. Shilajit has been used for centuries by the Ayurvedic Medicine for its antiaging properties and ability to increase strength and vitality. However, does Shilajit really work as people claim? That’s the question we seek to answer.

 

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Benefits of Shilajit

Fulvic Acid?  (FvA)

About Shilajit

Facts or Myth

What’s giving Shilajit this power? Shilajit’s unique composition as a phytocomplex is very rich in fulvic acid and selenium. fulvic acid, is known by its properties such as antioxidant, anti-inflammatory, and memory enhancer. Novel investigations indicate that fulvic acid is an antiaggregation factor of tau protein in vitro, which projects fulvic acid as a potential anti-Alzheimer’s disease molecule.

Shilajit also contains dipenzo-a-pyrones (DBPs) and chromoproteins (DCPs) and are potent antioxidants, which plays a powerful role in reducing inflammation.

What is Fulvic Acid? (FvA)

Facts or Myth

What is Fulvic Acid?  (FvA)

Fulvic Acid comes from humic substances produced by microorganisms in soil. Traditional medicine and modern research claim FvA can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function; all of which are hallmarks of diabetes.A randomized controlled trial shows treatment with Shilajit for 90 days at 250mg taken twice a day improved total testosterone, free testosterone and dehydroepiandrosterone compared to placebo. The most significant increase was DHEA, which is a precursor of testosterone. After 90 days, there was nearly a 32% increase in DHEA.Another study focused on bone mineral density in postmenopausal women with osteopenia. Supplementation with Shilajit at 250mg for 48- week treatment shown the increased bone turnover, inflammation and oxidative stress that coincides with estrogen deficiency.

What about antiaging?

Facts or Myth

A randomized control trial shows significantly increased type 1 collagen synthesis, and collagen is a protein that makes up our skin, eyes, bones, ligaments, tendons, and muscle. Supplementation with Shilajit has been shown to increase collagen synthesis. However, the trial was to see if collagen synthesis resulted in increased circulating levels. The results were supplementing with 500 and 1000mg increased type 1 collagen synthesis and circulating levels as indicated by serum pro-c1α1.

 

What about muscle Recovery?

A study received 63 recreationally active men who were randomly given a low dose, high dose, and a placebo group. After 8 weeks of supplementing with 500mg, participates in the high dose group elicited favorable muscle and connective tissue adaptations. Meaning, while exercising on maximal voluntary isometric contractions strength, concentric peak torque, fatigue-induced percent decline in strength and serum hydroxyproline, the high does group maintained maximal muscular strength following the fatiguing protocol.

Conclusion, the randomize control trials were completed by using PrimaVie purified Shilajit extract, which may contain very little heavy metals as compared to other products. Not all Shilajit products are equal and therefore results may vary. Shilajit is a powerful antioxidant, anti-inflammatory, memory enhancer and may prevent against Alzheimer’s disease.

Product Recommendation

Only trusted products backed by science 

The product in all randomized controlled trials were PrimaVie
Other Articles

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Creatine

Learn the benefits of creatine

Magnesium

All About Magnesium

There are many different forms of magnesium.

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How to lose fat

Learn how to lose fat and keep muscle.

References: 

Carrasco-Gallardo C, Guzmán L, Maccioni RB. Shilajit: a natural phytocomplex with potential procognitive activity. Int J Alzheimers Dis. 2012;2012:674142. doi: 10.1155/2012/674142. Epub 2012 Feb 23. PMID: 22482077; PMCID: PMC3296184.

Pandit, S., Biswas, S., Jana, U., De, R.K., Mukhopadhyay, S.C. and Biswas, T.K. (2016), Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers. Andrologia, 48: 570-575. https://doi.org/10.1111/and.12482

 Usharani Pingali, Chandrasekhar Nutalapati, Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial, Phytomedicine, Volume 105, 2022, 154334, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2022.154334.

Morgado, A., Tsampoukas, G., Sokolakis, I. et al. Do “testosterone boosters” really increase serum total testosterone? A systematic review. Int J Impot Res 36, 348–364 (2024). https://doi.org/10.1038/s41443-023-00763-9

Winkler J, Ghosh S. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018 Sep 10;2018:5391014. doi: 10.1155/2018/5391014. PMID: 30276216; PMCID: PMC6151376.

Neltner TJ, Sahoo PK, Smith RW, Anders JPV, Arnett JE, Schmidt RJ, Johnson GO, Natarajan SK, Housh TJ. Effects of 8 Weeks of Shilajit Supplementation on Serum Pro-c1α1, a Biomarker of Type 1

Beta-Alanine

Beta- Alanine

Hello I’m Your new trainer

Beta- Alanine

Muscle and endurance supplement with new cognitive benefits for mental health. 

Studies show that supplementation with Beta-alanine increase performance for higher intensity training. Also, beta-alanine supports muscle growth by aiding in muscle recovery and repair. 

Recent data suggests that B-alanine can result in carnosine elevations in the brain, which appears supplementation may increase resilience to post-traumatic stress disorder, mild traumatic brain injury and heat stress. 

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Save On Beta Alanine

Shop today!

Not just for exercise

More research suggest beta-alanine may help reduce anxiety, reduce aging, and protect against cognitive decline. 

Why should you take Beta Alanine?

Nothing Feels As Good As Being Fit

Beta- alanine promotes faster recovery between exercise or sets, and helps increase output. Beta-alanine is a precursor to carnosine, and carnosine reduces lactic acid accumulation in your muscles during exercise. Beta-alanine increases your time to exhaustion by reducing fatigue. During exercise, glucose is broken down. Muscle breakdown glucose into lactic acid and converts into lactate. Carnosine works as a buffer against acid by reducing lactate in the muscle. Since beta-alanine elevates carnosine, muscle experience less fatigue during training. 

Increase Recovery

While Training

Muscle Repair

Post exercise and recovery

Fat burning

Greater lean body mass

Check out top brands

Start working on your body today, and with our individual fitness program, already in 90 days you will see a totally different girl in the mirror.

References

  • Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. 2010 Jun;42(6):1162-73. doi: 10.1249/MSS.0b013e3181c74e38. PMID: 20479615.
  • Cimadevilla-Fernández-Pola E, Martínez-Roldán C, Maté-Muñoz JL, Guodemar-Pérez J, Sánchez-Calabuig MA, García-Fernández P, Hervás-Pérez JP, Hernández-Lougedo J. Effects of β-Alanine Supplementation on Subjects Performing High-Intensity Functional Training. Nutrients. 2024 Jul 19;16(14):2340. doi: 10.3390/nu16142340. PMID: 39064783; PMCID: PMC11280034.
  • Saunders B, Elliott-Sale K, Artioli GG, Swinton PA, Dolan E, Roschel H, Sale C, Gualano B. β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 2017 Apr;51(8):658-669. doi: 10.1136/bjsports-2016-096396. Epub 2016 Oct 18. PMID: 27797728.
  • Ostfeld I, Hoffman JR. The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers. Nutrients. 2023 Feb 19;15(4):1039. doi: 10.3390/nu15041039. PMID: 36839397; PMCID: PMC9961614.
  • Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37. doi: 10.1007/s00726-011-1200-z. Epub 2012 Jan 24. PMID: 22270875; PMCID: PMC3374095.
  • Trexler ET, Smith-Ryan AE, Stout JR, Hoffman JR, Wilborn CD, Sale C, Kreider RB, Jäger R, Earnest CP, Bannock L, Campbell B, Kalman D, Ziegenfuss TN, Antonio J. International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr. 2015 Jul 15;12:30. doi: 10.1186/s12970-015-0090-y. PMID: 26175657; PMCID: PMC4501114.
  • Bellinger PM. β-Alanine supplementation for athletic performance: an update. J Strength Cond Res. 2014 Jun;28(6):1751-70. doi: 10.1519/JSC.0000000000000327. PMID: 24276304.
  • Georgiou GD, Antoniou K, Antoniou S, Michelekaki EA, Zare R, Ali Redha A, Prokopidis K, Christodoulides E, Clifford T. Effect of Beta-Alanine Supplementation on Maximal Intensity Exercise in Trained Young Male Individuals: A Systematic Review and Meta-Analysis. Int J Sport Nutr Exerc Metab. 2024 Jul 19;34(6):397-412. doi: 10.1123/ijsnem.2024-0027. PMID: 39032921.
  • Huerta Ojeda Á, Tapia Cerda C, Poblete Salvatierra MF, Barahona-Fuentes G, Jorquera Aguilera C. Effects of Beta-Alanine Supplementation on Physical Performance in Aerobic-Anaerobic Transition Zones: A Systematic Review and Meta-Analysis. Nutrients. 2020 Aug 19;12(9):2490. doi: 10.3390/nu12092490. PMID: 32824885; PMCID: PMC7551186.
  • Maté-Muñoz JL, Lougedo JH, Garnacho-Castaño MV, Veiga-Herreros P, Lozano-Estevan MDC, García-Fernández P, de Jesús F, Guodemar-Pérez J, San Juan AF, Domínguez R. Effects of β-alanine supplementation during a 5-week strength training program: a randomized, controlled study. J Int Soc Sports Nutr. 2018 Apr 25;15:19. doi: 10.1186/s12970-018-0224-0. PMID: 29713250; PMCID: PMC5918575.
  • Ostfeld I, Ben-Zeev T, Zamir A, Levi C, Gepner Y, Springer S, Hoffman JR. Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study. Nutrients. 2023 Feb 12;15(4):923. doi: 10.3390/nu15040923. PMID: 36839281; PMCID: PMC9960300.

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Cocoa Can Save Your Life

Cocoa Powder

Health Benefits

Cocoa_Powder

Cocoa Powder

Why should you add it to your diet

Cocoa Powder might be a great addition to your diet to improve your health. Cocoa contains polyphenols, which are naturally occurring antioxidants. Cocoa also contains flavanols, and data shows that flavanols can reduce inflammation. 

Theobromine

And other Anti-oxidants

Theobromine found in cocoa is a natural alkaloid. Similar to caffeine’s affect on adenosine to make us feel more awake and alert, theobromine works similarly without  the jitters or stimulating affects of caffeine. Theobromine provides neuroprotection against age-related cognitive impairments such as Alzheimer’s and Parkinson’s disease. In regards to weight loss, theobromine enhances fat breakdown and contributes to weight reduction.   The benefits of theobromine include: 

Summary of benefits

Take the first step to your healthiest self.

Cocoa powder offers numerous health benefits when consumed in moderation as part of a balanced diet. Rich in antioxidants, particularly flavonoids, it helps combat oxidative stress, reducing inflammation and potentially lowering the risk of chronic diseases like heart disease and cancer. It supports cardiovascular health by improving blood flow, lowering blood pressure, and enhancing cholesterol levels. Cocoa powder also contains minerals such as magnesium, iron, and potassium, which support muscle function, oxygen transport, and electrolyte balance. Additionally, it may boost mood and cognitive function due to compounds like theobromine and phenylethylamine, which can promote feelings of well-being and mental clarity. Its low calorie and fat content, especially in unsweetened varieties, makes it a versatile ingredient for healthy recipes.

Best way to eat cocoa Power?

eat delicious while burning extra fat

Cocoa powder should be at least 75% cocoa. However, data suggests a higher percentage promotes better health outcomes. You can add cocoa powder to smoothies, cereals, oatmeal, baked goods, pancakes, coffee, yogurt, mix with peanut butter or add to fruit.

References


  • Journal Article A Hahn, Joshua A Virk, Hafeez Ul Hassan A Wang, Zhen A Tang, Wai Hong WA Krittanawong, Chayakrit
     T Abstract 14006: Cardiovascular Health Benefits of Theobromine in Cacao and Chocolate D 2021 J Circulation P A14006-A14006 V 144 N Suppl_1 R doi:10.1161/circ.144.suppl_1.14006 U https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.14006
  • Mengjuan Zhang, Haifeng Zhang, Lu Jia, Yi Zhang, Runwen Qin, Shihua Xu, Yingwu Mei,
    Health benefits and mechanisms of theobromine,
    Journal of Functional Foods,
    Volume 115, 2024, 106126,
    ISSN 1756-4646, https://doi.org/10.1016/j.jff.2024106126.
  • Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015 Feb 20;6:30. doi: 10.3389/fphar.2015.00030. PMID: 25750625; PMCID: PMC4335269.
  • Fusar-Poli L, Gabbiadini A, Ciancio A, Vozza L, Signorelli MS, Aguglia E. The effect of cocoa-rich products on depression, anxiety, and mood: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62(28):7905-7916. doi: 10.1080/10408398.2021.1920570. Epub 2021 May 10. PMID: 33970709.
  • Jackson SE, Smith L, Firth J, Grabovac I, Soysal P, Koyanagi A, Hu L, Stubbs B, Demurtas J, Veronese N, Zhu X, Yang L. Is there a relationship between chocolate consumption and symptoms of depression? A cross-sectional survey of 13,626 US adults. Depress Anxiety. 2019 Oct;36(10):987-995. doi: 10.1002/da.22950. Epub 2019 Jul 29. PMID: 31356717.
  • Ludovici V, Barthelmes J, Nägele MP, Enseleit F, Ferri C, Flammer AJ, Ruschitzka F, Sudano I. Cocoa, Blood Pressure, and Vascular Function. Front Nutr. 2017 Aug 2;4:36. doi: 10.3389/fnut.2017.00036. PMID: 28824916; PMCID: PMC5539137.
  • Lin X, Zhang I, Li A, Manson JE, Sesso HD, Wang L, Liu S. Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nutr. 2016 Nov;146(11):2325-2333. doi: 10.3945/jn.116.237644. Epub 2016 Sep 28. PMID: 27683874; PMCID: PMC5086796.
  • De Araujo QR, Gattward JN, Almoosawi S, Silva Md, Dantas PA, De Araujo Júnior QR. Cocoa and Human Health: From Head to Foot–A Review. Crit Rev Food Sci Nutr. 2016;56(1):1-12. doi: 10.1080/10408398.2012.657921. PMID: 24915376.
  • De Araujo QR, Gattward JN, Almoosawi S, Silva Md, Dantas PA, De Araujo Júnior QR. Cocoa and Human Health: From Head to Foot–A Review. Crit Rev Food Sci Nutr. 2016;56(1):1-12. doi: 10.1080/10408398.2012.657921. PMID: 24915376.
  • Zhao B, Gan L, Yu K, Männistö S, Huang J, Albanes D. Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis. Eur J Epidemiol. 2022 Apr;37(4):321-333. doi: 10.1007/s10654-022-00858-5. Epub 2022 Apr 23. PMID: 35460393; PMCID: PMC11329947.
  • Ried K, Fakler P, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD008893. doi: 10.1002/14651858.CD008893.pub3. PMID: 28439881; PMCID: PMC6478304.
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Taurine

Taurine

A secret supplement for longevity and health?

Taurine

May help prevent cardiovascular disease, increase lifespan, and more

Taurine is an amino acid that occurs naturally in the body and is found in many foods. It’s considered semi-essential or conditionally essential because it’s derived from cysteine like other amino acids but lacks a carboxyl group. Instead, it contains a sulfide group and can be called an amino sulfonic acid.

Taurine helps with bodily functions, including those of the digestive, cardiovascular, skeletal, muscular, and nervous systems. It also works as a neurotransmitter in the brain and is used for energy production. Taurine has antioxidant and anti-inflammatory properties that may enhance insulin sensitivity, which could reduce the risk of type 2 diabetes or improve blood sugar management
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Science Based Fitness

ON A REGULAR BASIS CAN BE VERY BENEFICIAL TO YOUR

HEALTH

Improve Health

Introduction to chronic inflammation

Recent studies show chronic inflammation may be the greatest contribution to disease, or a cornerstone for the development of cardiovascular disease. Other major heath factors include pollution, environmental stresses, drugs, excess food consumption and obesity.  Obesity is a major contribution to negative health outcomes. Managing a health body mass is crucial in over health. Taurine may help heart health and enhance endothelial function, which may significantly reduce the risk of atherosclerosis and cardiovascular events.  Taurine accounts for 50% of the total free amino acids in the heart, and it’s been shown to enhance cardiac contractility and improve heart function. 

Taurine is abundant in skeletal muscle, but the largest benefit of taurine is glucose and lipid regulation, energy metabolism, anti-inflammatory modulation and antioxidant action. Taurine may also aid in athletic performance such as muscle repair and cardiovascular improvements.

Conclusion

Taurine, an amino acid found naturally in the body and certain foods, offers multiple health benefits when included in a balanced diet or as a supplement. It plays a crucial role in cardiovascular health by regulating blood pressure, reducing cholesterol levels, and improving heart function, potentially lowering the risk of heart disease. Taurine supports neurological health by acting as a neuroprotective agent, aiding in brain development, and potentially reducing symptoms of anxiety and stress. It also enhances insulin sensitivity, which may help manage blood sugar levels and reduce the risk of type 2 diabetes. Additionally, taurine’s antioxidant and anti-inflammatory properties help combat oxidative stress, supporting overall cellular health. Its role in muscle function and hydration makes it popular in sports supplements, as it may improve exercise performance and reduce muscle fatigue.

Taurine

Shop Now

References

Citations 

  • Lin Guan, Peng Miao, The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials, European Journal of Pharmacology, Volume 885, 2020, 173533,ISSN 0014-2999,
  • Santulli G, Kansakar U, Varzideh F, Mone P, Jankauskas SS, Lombardi A. Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients. 2023; 15(19):4236. https://doi.org/10.3390/nu15194236
  • Ahmadian M, Roshan VD, Aslani E, Stannard SR. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Therapeutic Advances in Cardiovascular Disease. 2017;11(7):185-194. doi:10.1177/1753944717711138
  • Ahmadian, M., Dabidi Roshan, V., & Ashourpore, E. (2017). Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure. Journal of Dietary Supplements14(4), 422–432. https://doi.org/10.1080/19390211.2016.1267059
  • Kurtz, J. A., VanDusseldorp, T. A., Doyle, J. A., & Otis, J. S. (2021). Taurine in sports and exercise. Journal of the International Society of Sports Nutrition18(1). https://doi.org/10.1186/s12970-021-00438-0

Fat loss

How to lose fat

Backed by science 

Burn Fat

The secret to weight loss backed by science

By now, you’ve probably heard of all the different weight loss diets. There is Keto, Atkins, carnivore, whole foods, vegan, vegetarian, plant based, animal based, and many more. What do these diets have in common? The elimination of processed or sugary foods. However, all diets have one thing in common, and that is the reduction of calories by eliminating more caloric dense foods. 

It seems every couple of years the health industry cycles on diets based on trending topics. It’s unfortunate in the realm of fitness and health, the industry tries to sell so many products and plans. The truth behind weight loss is far more boring, and due to its boring and consistent nature, the industry works to start controversy.  The good news for you is Science Based Fitness provides you with all the information, so you don’t have to buy anything! This is a complete guide to help you lose weight and keep it off without the promotion of fad diets that don’t work long term. 

There’s a lot of “social media influencers” whose job is to sell products, so they make money. Now profit isn’t a bad thing if you’re truly helping people, but most people just want to help people buy a product or plan. At Science Based Fitness, we believe information should be FREE. We don’t want to profit from you. Instead, we want you to live your best life. We may recommend products, but our business model is to keep the mission running. 

There’s no single “secret” to weight loss, but sustainable success hinges on a consistent calorie deficit—consuming fewer calories than you burn—while prioritizing nutrient-dense foods and regular physical activity. A balanced diet rich in whole foods like vegetables, lean proteins, healthy fats, and complex carbohydrates supports satiety and health, while avoiding overly restrictive or fad diets that are hard to maintain. Regular exercise, combining strength training and cardio, boosts metabolism and preserves muscle mass. Behavioral changes, like mindful eating, proper sleep, and stress management, are critical, as emotional eating or hormonal imbalances can derail progress. Tracking food intake and activity, setting realistic goals, and staying patient with gradual progress (aiming for 0.5-2 pounds lost per week) are key. No magic pills or shortcuts exist—consistency, moderation, and lifestyle changes tailored to your needs drive long-term results. Always consult a healthcare professional before starting any weight loss plan.

The Science behind weight loss

Are carbohydrates bad and make you fat?

Does fat make you fat?

Is red meat bad?

Is high LDL good or bad?

Is insulin spikes bad?

Should you reduce the time you eat meals? 

Chances are you’ve heard these claims time and time again, and you might even listen to a medical professional make these exact claims. However, in the world of science, nothing it true until it can be proven. 

The truth is any diet can work if you stick to it and it puts you in a caloric deficit. A lot of people will debate the calories in vs. calories out logic based on the thermodynamics of foods and energy balance. However, the truth is based on all scientific studies, Weight loss occurs regardless of what calories are reduced from carbohydrates, fats, and proteins. 

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The science Is clear

A caloric deficit is the most important factor for weight loss

Breaking Myths

The secret to weight loss backed by science

Science is clear…. The available evidence shows that weight loss occurs following a reduction in daily caloric intake, regardless of the macronutrient origin of those calories, although the magnitude of weight loss varies according to the type of macronutrient, and the effects on diet-induced thermogenesis.

This is a more simple and logical approach to weight loss. Enjoy the foods you like while focusing more on lean meats, fruits, vegetables, nuts and seeds. However, it’s good to be aware of calories. For example, fat contains 9 calories per-gram, so foods with a lot of fat tend to be more calorically dense. This is where foods with fiber come into play because it helps keep you full and may prevent overeating. Foods that contain higher amounts of fiber will help reduce hunger, and therefore people tend to eat less. We’ll explain more about the importance of fiber and its relation to the gut microbiome in another article. 

Diet and Trends

A lot of diets can be trendy and popular because they’re new and different. Ask anybody builder what they think of chicken, broccoli, and rice. It’s very bland and boring, but it works because you have lean protein, healthy vegetables with fiber, and a healthy carbohydrate source. The structure of that meal has proper proportion macronutrients. (Macronutrients are proteins, fats, and carbohydrates.) Many diets try to adjust caloric intake by reducing macronutrients. For example, keto, Atkins, Carnivore are all low-carbohydrate diets. In nearly all randomized control trials, there’s almost zero difference in weight loss when comparing low carbohydrate to low fat, so this raises the question, how do we lose weight? It’s truly simple when you focus on caloric restriction, then you can enjoy the foods you like while being at a healthy weight. 

If it’s all about calories, then why eat healthy?

Heathy foods, meaning, whole foods are simply better by nature. Most whole foods are less processed, so they have more fiber and less refined sugar added. Let’s look at an apple, for example. An apple contains 95 calories, 3 grams of fiber, and is packed with phytonutrients like antioxidants, vitamins and minerals. Compare an apple to Coke that contains 150 calories with zero fiber, no vitamins and minerals, and you’ll notice the Coke product didn’t leave you feeling full. Some data suggest the Coke beverage may lead you to eating a surplus of calories due to the higher sugar content with zero fiber. A whole apple compared to apple juice is also different. Apple juice goes through a filter and pasteurization process that removes fiber and some vitamins and minerals. Also, sugar is added to sweeten the beverage, so apple juice contains more calories than an apple. This is how people get into a caloric surplus because it’s very simple to over consume calories. 

 

Optimal Nutrition

So, now we understand the logic behind weight loss. However, what’s an optimal diet? Optimal nutrition is defined by the best foods to maximize healthy outcomes. In other words, optimal nutrition means to provide the body with the most nutrient dense foods to increase lifespan and performance. Metabolically, this means choosing foods with the most beneficial components will keep your body at optimal health to prevent disease. Regardless of some influencers claim, the data is clear. 

Focus on lean meats, fish, healthy carbohydrates like rice, oatmeal, legumes, vegetables, fruits, nuts, and seeds. As we continue to learn about the gut microbiome and its complexity, it’s important to consume foods high in fiber as fiber helps feed good bacteria while eliminating bad. A lot of data concludes a Mediterranean diet would be the most beneficial diet for health and longevity. The Mediterranean Diet focuses on mostly lean meats, fish, grains, fruits, vegetables, nuts and seeds while limiting red meats. The Mediterranean diet is one of the most studied and well-known dietary patterns. 

Regarding optimal nutrition, it’s important to know that all foods have value. Wait, even Coke products have value? Regarding living, yes, any source of calories has value to sustain life. Humans didn’t always have an abundance of food available. So whatever foods were available was valuable. For example, red meat has value. Red meat contains proteins, vitamins, minerals, creatine, essential amino acids, and healthy fats. However, red meat also contains a lot of saturated fat, cholesterol, and no fiber. It would be wise to pair red meat with foods with fiber, low in fat and cholesterol, and other vitamins and minerals red meat doesn’t contain. This is the notion behind optimal nutrition. Optimally selecting foods to complement each other and what they’re lacking to promote better health. 

It's still possible to enjoy the foods you like while being in a deficit. Energy balance is the key to weight loss.

Sports Nutrition

For athletes or even average gym participants, it’s important to balance protein, carbohydrates, and fats. Eliminating a macronutrient will put you at a disadvantage. The scientific literature is sound on this notion. Eliminating carbohydrates may result in muscle loss due to the depletion of muscle glycogen. As a result, the muscle will look flat. Also, muscle growth will be limited. The style of training will account for overall caloric intake, protein and carbohydrate requirements. For example, an endurance runner will require more carbohydrates due to the consistent running. 

References

1. Ludwig DS, Willett WC, Volek JS, Neuhouser ML. Dietary fat: from foe to friend? Science. (2018) 362:764–70. doi: 10.1126/science.aau2096

CrossRef Full Text | Google Scholar

2. Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, et al. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med. (2010) 153:147–57. doi: 10.7326/0003-4819-153-3-201008030-00005

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Ebbeling CB, Feldman HA, Klein GL, Wong JMW, Bielak L, Steltz SK, et al. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. BMJ. (2018) 363:k4583. doi: 10.1136/bmj.k4583

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Hall KD, Bemis T, Brychta R, Chen KY, Courville A, CRayner EJ, et al. Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metab. (2015) 22:427–36. doi: 10.1016/j.cmet.2015.07.021

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Hall KD, Guo J. Obesity energetics: body weight regulation and the effects of diet composition. Gastroenterology. (2017) 152:1718–27.e1713. doi: 10.1053/j.gastro.2017.01.052

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Swiglo BA, Murad MH, Schünemann HJ, Kunz R, Vigersky RA, Guyatt GH, et al. A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J Clin Endocrinol Metab. (2008) 93:666–73. doi: 10.1210/jc.2007-1907

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Freire R. Scientific evidence of diets for weight loss: different macronutrient composition, intermittent fasting, and popular diets. Nutrition. (2020) 69:110549. doi: 10.1016/j.nut.2019.07.001

PubMed Abstract | CrossRef Full Text | Google Scholar

8. Muscogiuri G, Barrea L, Laudisio D, Pugliese G, Salzano C, Savastano S, et al. The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide. J Trans Med. (2019) 17:356. doi: 10.1186/s12967-019-2104-z

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Caprio M, Infante M, Moriconi E, Armani A, Fabbri A, Mantovani G, et al. Very-low-calorie ketogenic diet [VLCKD] in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology [SIE]. J Endocrinol Invest. (2019) 42:1365–86. doi: 10.1007/s40618-019-01061-2

CrossRef Full Text | Google Scholar

10. Bueno NB, de Melo IS, de Oliveira SL, da Rocha Ataide T. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomized controlled trials. Br J Nutr. (2013) 110:1178–87.21. doi: 10.1017/S0007114513000548

CrossRef Full Text | Google Scholar

11. Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate [ketogenic] diets. Eur J Clin Nutr. (2013) 67:789–96. doi: 10.1038/ejcn.2013.116

CrossRef Full Text | Google Scholar

12. Cicero AF, Benelli M, Brancaleoni M, Dainelli G, Merlini D, Negri R. Middle and long-term impact of a very low-carbohydrate ketogenic diet on cardiometabolic factors: a multi-center, cross-sectional, clinical study. High Blood Press Cardiovasc Prev. (2015) 22:389–94. doi: 10.1007/s40292-015-0096-1

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Moreno B, Bellido D, Sajoux I, Goday A, Saavedra D, Crujeiras AB, et al. Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity. Endocrine. (2014) 47:793–805. doi: 10.1007/s12020-014-0192-3

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Merra G, Miranda R, Barrucco S, Gualtieri P, Mazza M, Moriconi E, et al. Very-low-calorie ketogenic diet with aminoacid supplement versus very low restricted-calorie diet for preserving muscle mass during weight loss: a pilot double-blind study. Eur Rev Med Pharmacol Sci. (2016) 20:2613–21.

PubMed Abstract | Google Scholar

15. Bistrian DR, Winterer J, Blackburn GL, Young V, Sherman M. Effect of a protein-sparing diet and brief fast on nitrogen metabolism in mildly obese subjects. J Lab Clin Med. (1977) 89:1030–5.

PubMed Abstract

16. Blackburn GL, Bray GA. Management of Obesity by Severe Caloric Restriction. Littleton: PSG Publishing Company, Inc. (1985).

Google Scholar

17. Avenell A, Brown TJ, McGee MA, Campbell MK, Grant AM, Broom J, et al. What are the long term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials. J Hum Nutr Diet. (2004) 17:317–35. doi: 10.1111/j.1365-277X.2004.00531.x

CrossRef Full Text | Google Scholar

18. Walters JK, Hoogwerf BJ, Reddy SS. The protein sparing modified fast for obesity-related medical problems. Cleve Clin J Med. (1997) 64:242–4 doi: 10.3949/ccjm.64.5.242

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Bakhach M, Shah V, Harwood T, Lappe S, Bhesania N, Mansoor S, et al. The protein-sparing modified fast diet: an effective and safe approach to induce rapid weight loss in severely obese adolescents. Glob Pediatr Health. (2016) 3:2333794X15623245. doi: 10.1177/2333794X15623245

PubMed Abstract | CrossRef Full Text | Google Scholar

20. Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH. Pediatric obesity-assessment, treatment, and prevention: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. (2017) 102:709–57. doi: 10.1210/jc.2016-2573

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Van Gaal LF, Snyders D, De Leeuw IH, Bekaert JL. Anthropometric and calorimetric evidence for the protein sparing effects of a new protein supplemented low calorie preparation. Am J Clin Nutr. (1985) 41:540–4. doi: 10.1093/ajcn/41.3.540

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Martin WF, Cerundolo LH, Pikosky MA, Gaine PC, Maresh CM, Armstrong LE, et al. Effects of dietary protein intake on indexes of hydration. J Am Dietetic Assoc. (2006) 106:587–9. doi: 10.1016/j.jada.2006.01.011

PubMed Abstract | CrossRef Full Text | Google Scholar

23. Walrand S, Short KR, Bigelow ML, Sweatt AJ, Hutson SM, Nair KS. Functional impact of high protein intake on healthy elderly people. Am J Physiol Endocrinol Metab. (2008) 295:E921–8. doi: 10.1152/ajpendo.90536.2008

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Reddy ST, Wang CY, Sakhaee K, Brinkley L, Pak CY. Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism. Am J Kidney Dis. (2002) 40:265–74. doi: 10.1053/ajkd.2002.34504

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV. Reversal of diabetic nephropathy by a ketogenic diet. PLoS ONE. (2011) 6:e18604. doi: 10.1371/journal.pone.0018604

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Festi D, Colecchia A, Larocca A, Villanova N, Mazzella G, Petroni ML, et al. Review: low caloric intake and gall-bladder motor function. Alimentary Pharmacol Ther. (2000) 14 (Suppl. 2):51–3. doi: 10.1046/j.1365-2036.2000.014s2051.x

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Bonjour JP. Dietary protein: an essential nutrient for bone health. J Am Coll Nutr. (2005) 24:526S−36S. doi: 10.1080/07315724.2005.10719501

PubMed Abstract | CrossRef Full Text | Google Scholar

28. Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr. (2009) 90:1674–92. doi: 10.3945/ajcn.2009.27799

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Weber DD, Aminazdeh-Gohari S, Kofler B. Ketogenic diet in cancer therapy. Aging. (2018) 10:164–5. doi: 10.18632/aging.101382

CrossRef Full Text | Google Scholar

30. Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B. Ketogenic diet in the treatment of cancer – Where do we stand? Mol Metab. (2019) 33:102–21. doi: 10.1016/j.molmet.2019.06.026

PubMed Abstract | CrossRef Full Text | Google Scholar

31. Woolf EC, Scheck AC. The ketogenic diet for the treatment of malignant glioma. J Lipid Res. (2015) 56:5–10. doi: 10.1194/jlr.R046797

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Bartmann C, Janaki Raman SR, Flöter J, Schulze A, Bahlke K, Willingstorfer J, et al. Beta-hydroxybutyrate [3-OHB] can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation. Cancer Metab. (2018) 6:8. doi: 10.1186/s40170-018-0180-9

CrossRef Full Text | Google Scholar

33. Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P, et al. The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS ONE. (2012) 7:e36197. doi: 10.1371/journal.pone.0036197

PubMed Abstract | CrossRef Full Text | Google Scholar

34. Winter SF, Loebel F, Dietrich J. Role of ketogenic metabolic therapy in malignant glioma: a systematic review. Crit Rev Oncol Hematol. (2017) 112:41–58. doi: 10.1016/j.critrevonc.2017.02.016

PubMed Abstract | CrossRef Full Text | Google Scholar

35. van der Louw EJTM, Olieman JF, van den Bemt PMLA, Bromberg JEC, Oomen-de Hoop E, Neuteboom RF, et al. Ketogenic diet treatment as adjuvant to standard treatment of glioblastoma multiforme: a feasibility and safety study. Ther Adv Med Oncol. (2019) 11:1758835919853958. doi: 10.1177/1758835919882584

PubMed Abstract | CrossRef Full Text | Google Scholar

36. Schwartz KA, Noel M, Nikolai M, Chang HT. Investigating the ketogenic diet as treatment for primary aggressive brain cancer: challenges and lessons learned. Front Nutr. (2018) 5:11. doi: 10.3389/fnut.2018.00011

PubMed Abstract | CrossRef Full Text | Google Scholar

37. Rieger J, Bähr O, Maurer GD, Hattingen E, Franz K, Brucker D, et al. ERGO: a pilot study of ketogenic diet in recurrent glioblastoma. Int J Oncol. (2014) 44:1843–52. doi: 10.3892/ijo.2014.2382

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Kossoff EH, Dorward JL. The modified Atkins diet. Epilepsia. (2008) 49:37–41. doi: 10.1111/j.1528-1167.2008.01831.x

CrossRef Full Text | Google Scholar

39. Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. (2007) 297:969–77. doi: 10.1001/jama.297.9.969

PubMed Abstract | CrossRef Full Text | Google Scholar

40. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med. (2008) 359:229–41. doi: 10.1056/NEJMoa0708681

CrossRef Full Text | Google Scholar

41. Westerterp-Plantenga MS, Lemmens SG, Westerterp KR. Dietary protein—its role in satiety, energetics, weight loss and health. Br J Nutr. (2012) 108:S105–12. doi: 10.1017/S0007114512002589

PubMed Abstract | CrossRef Full Text | Google Scholar

42. Gardner CD, Trepanowski JF, Del Gobbo LC, Hauser ME, Rigdon J, Ioannidis JPA, et al. Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: the DIETFITS randomized clinical trial. JAMA. (2018) 319:667–79. doi: 10.1001/jama.2018.0245

PubMed Abstract | CrossRef Full Text | Google Scholar

43. Truby H, Baic S, deLooy A, Fox KR, Livingstone MBE, Logan CM, et al. Randomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC “diet trials.” BMJ. (2006) 332:1309–14. doi: 10.1136/bmj.38833.411204.80

PubMed Abstract | CrossRef Full Text | Google Scholar

44. Dalle Grave R, Calugi S, Gavasso I, El Ghoch M, Marchesini G. A randomized trial of energy-restricted high-protein versus high-carbohydrate, low-fat diet in morbid obesity. Obesity. (2013) 21:1774–81. doi: 10.1002/oby.20320

PubMed Abstract | CrossRef Full Text | Google Scholar

45. Mansoor N, Vinknes KJ, Veierød MB, Retterstøl K. Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a metaanalysis of randomised controlled trials. Br J Nutr. (2016) 115:466–79. doi: 10.1017/S0007114515004699

PubMed Abstract | CrossRef Full Text | Google Scholar

46. Retterstøl K, Svendsen M, Narverud I, Holven KB. Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: a randomized controlled study. Atherosclerosis. (2018) 279:52–61. doi: 10.1016/j.atherosclerosis.2018.10.013

PubMed Abstract | CrossRef Full Text | Google Scholar

47. Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. (2009) 360:859–73. doi: 10.1056/NEJMoa0804748

PubMed Abstract | CrossRef Full Text | Google Scholar

48. Eaton SB, Konner M. Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med. (1985) 312:283–9. doi: 10.1056/NEJM198501313120505

PubMed Abstract | CrossRef Full Text | Google Scholar

49. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, et al. Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr. (2005) 81:341–54. doi: 10.1093/ajcn.81.2.341

PubMed Abstract | CrossRef Full Text | Google Scholar

50. Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD. Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter gatherer diets. Am J Clin Nutr. (2000) 71:682–92. doi: 10.1093/ajcn/71.3.682

PubMed Abstract | CrossRef Full Text | Google Scholar

51. Pastore RL, Brooks JT, Carbone JW. Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations. Nutr Res. (2015) 35:474–9. doi: 10.1016/j.nutres.2015.05.002

PubMed Abstract | CrossRef Full Text | Google Scholar

52. Manheimer EW, van Zuuren EJ, Fedorowicz Z, Pijl H. Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis. Am J Clin Nutr. (2015) 102:922–32. doi: 10.3945/ajcn.115.113613

PubMed Abstract | CrossRef Full Text | Google Scholar

53. Jonsson T, Ahr_en B, Pacini G, Sundler F, Wierup N, Steen S, et al. A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab. (2006) 3:39. doi: 10.1186/1743-7075-3-39

PubMed Abstract | CrossRef Full Text | Google Scholar

54. Jonsson T, Granfeldt Y, Ahr_en B, Branell US, Palsson G, Hansson A, et al. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. (2009) 8:35. doi: 10.1186/1475-2840-8-35

PubMed Abstract | CrossRef Full Text | Google Scholar

55. Ghaedi E, Mohammadi M, Mohammadi H, Ramezani-Jolfaie N, Malekzadeh J, Hosseinzadeh M, et al. Effects of a Paleolithic diet on cardiovascular disease risk factors: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. (2019) 10:634–46. doi: 10.1093/advances/nmz007

PubMed Abstract | CrossRef Full Text | Google Scholar

56. Jonsson T, Granfeldt Y, Erlanson-Albertsson C, Ahrén B, Lindeberg S. A Paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab. (2010) 7:85. doi: 10.1186/1743-7075-7-85

PubMed Abstract | CrossRef Full Text | Google Scholar

57. Bligh HF, Godsland IF, Frost G, Hunter KJ, Murray P, MacAulay K, et al. Plantrich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study. Br J Nutr. (2015) 113:574–84. doi: 10.1017/S0007114514004012

PubMed Abstract | CrossRef Full Text | Google Scholar

58. Spreadbury I. Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity. Diabetes Metab Syndr Obes. (2012) 5:175–89. doi: 10.2147/DMSO.S33473

PubMed Abstract | CrossRef Full Text | Google Scholar

59. Jonsson T, Granfeldt Y, Lindeberg S, Hallberg AC. Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes. Nutr J. (2013) 12:105. doi: 10.1186/1475-2891-12-105

PubMed Abstract | CrossRef Full Text | Google Scholar

60. Osterdahl M, Kocturk T, Koochek A, W€andell PE. Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr. (2008) 62:682–5. doi: 10.1038/sj.ejcn.1602790

PubMed Abstract | CrossRef Full Text | Google Scholar

61. Otten J, Stomby A, Waling M, Isaksson A, Tellstrom A, Lundlin-Olsson L, et al. Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes. Diabetes Metab Res Rev. (2017) 33:e2828. doi: 10.1002/dmrr.2828

PubMed Abstract | CrossRef Full Text | Google Scholar

62. Mellberg C, Sandberg S, Ryberg M, Eriksson M, Brage S, Larsson C, et al. Long term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial. Eur J Clin Nutr. (2014) 68:350–7. doi: 10.1038/ejcn.2013.290

PubMed Abstract | CrossRef Full Text | Google Scholar

63. Otten J, Mellberg C, Ryberg M, Sandberg S, Kullberg J, Lindahl B, et al. Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention. Int J Obes. (2016) 40:747–53. doi: 10.1038/ijo.2016.4

PubMed Abstract | CrossRef Full Text | Google Scholar

64. Manousou S, Sta_ l M, Larsson C, Mellberg C, Lindahl B, Eggersten R, et al. A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women. Eur J Clin Nutr. (2018) 72:124–9. doi: 10.1038/ejcn.2017.134

PubMed Abstract | CrossRef Full Text | Google Scholar

65. Pitt CE. Cutting through the Paleo hype: the evidence for the Palaeolithic diet. Aust Fam Physician. (2016) 45:35–8.

PubMed Abstract | Google Scholar

66. Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat Rev Neurosci. (2018) 19:63–80. doi: 10.1038/nrn.2017.156

PubMed Abstract | CrossRef Full Text | Google Scholar

67. Halberg N, Henriksen M, S€oderhamn N, Stallknecht B, Ploug T, Schjerling P, et al. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol. (2005) 99:2128–36. doi: 10.1152/japplphysiol.00683.2005

PubMed Abstract | CrossRef Full Text | Google Scholar

68. Varady KA, Bhutani S, Church EC, Klempel MC. Short-term modified alternate- day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr. (2009) 90:1138–43. doi: 10.3945/ajcn.2009.28380

PubMed Abstract | CrossRef Full Text | Google Scholar

69. Eshghinia S, Mohammadzadeh F. The effects of modified alternate-day fasting diet on weight loss and CAD risk factors in overweight and obese women. J Diabetes Metab Disord. (2013) 12:4. doi: 10.1186/2251-6581-12-4

PubMed Abstract | CrossRef Full Text | Google Scholar

70. Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, et al. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA. (2003) 100:6216–20. doi: 10.1073/pnas.1035720100

PubMed Abstract | CrossRef Full Text | Google Scholar

71. Varady KA. Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Obes Rev. (2011) 12:e593–601. doi: 10.1111/j.1467-789X.2011.00873.x

PubMed Abstract | CrossRef Full Text | Google Scholar

72. Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med. (2007) 42:665–74. doi: 10.1016/j.freeradbiomed.2006.12.005

PubMed Abstract | CrossRef Full Text | Google Scholar

73. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, et al. Fasting-mimicking diet promotes Ngn3-driven β-cell regeneration to reverse diabetes. Cell. (2017) 168:775–88.e12. doi: 10.1016/j.cell.2017.01.040

PubMed Abstract | CrossRef Full Text | Google Scholar

74. Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernathy DR, et al. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. (2006) 20:631–7. doi: 10.1096/fj.05-5263com

PubMed Abstract | CrossRef Full Text | Google Scholar

75. de Groot S, Vreeswijk MP, Welters MJ, Gravesteijn G, Boei JJ, Jochems A, et al. The effects of short-term fasting on tolerance to [neo] adjuvant chemotherapy in HER2-negative breast cancer patients: a randomised pilot study. BMC Cancer. (2015) 15:652. doi: 10.1186/s12885-015-1663-5

CrossRef Full Text | Google Scholar

76. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, et al. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. (2016) 16:360. doi: 10.1186/s12885-016-2370-6

PubMed Abstract | CrossRef Full Text | Google Scholar

77. Bauersfeld SP, Kessler CS, Wischnewsky M, Jaensch A, Steckhan N, Stange R, et al. The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer:a randomised cross-over pilot study. BMC Cancer. (2018) 18:476. doi: 10.1186/s12885-018-4353-2

CrossRef Full Text | Google Scholar

78. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. (2017) 36:11–48. doi: 10.1016/j.clnu.2016.07.015

PubMed Abstract | CrossRef Full Text | Google Scholar

79. Fontana L, Patridge L. Promoting health and longevity through diet: from model organisms to humans, Cell. (2015) 161:106–18. doi: 10.1016/j.cell.2015.02.020

CrossRef Full Text | Google Scholar

80. Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol. (2007) 42:709–12. doi: 10.1016/j.exger.2007.03.009

CrossRef Full Text | Google Scholar

81. Dirks AJ, Leeuwenburgh C. Caloric restriction in humans: potential pitfalls and health concerns. Mech Ageig Dev. (2006) 127:1–7. doi: 10.1016/j.mad.2005.09.001

PubMed Abstract | CrossRef Full Text | Google Scholar

82. Das SK, Roberts SB, Bhapkar MV, Villareal DT, Fontana L, Martin CK, et al. Body-composition changes in the comprehensive assessment of long-term effects of reducing intake of energy [CALERIE]-2 study: a 2-y randomised controlled trial of calorie restriction in non obese humans. Am J Clin Nutr. (2017) 105:913–27. doi: 10.3945/ajcn.116.137232

CrossRef Full Text | Google Scholar

83. Jospe MR, Roy M, Brown RC, Haszard JJ, Meredith-Jones K, Fangupo LJ, et al. Intermittent fasting, Paleolithic, or Mediterranean diets in the real world: exploratory secondary analyses of a weight-loss trial that included choice of diet and exercise. Am J Clin Nutr. 111:503–14. doi: 10.1093/ajcn/nqz330

PubMed Abstract | CrossRef Full Text | Google Scholar

84. Headland M, Clifton P, Carter S, Keogh J. Weight-loss outcomes: a systematic review and meta-analysis of intermittent energy restriction trials lasting a minimum of 6 months. Nutrients. (2016) 8:354. doi: 10.3390/nu8060354

PubMed Abstract | CrossRef Full Text | Google Scholar

85. Antoni R, Johnston KL, Collins AL, Robertson MD. Effects of intermittent fasting on glucose and lipid metabolism. Proc Nutr Soc. (2017) 76:361–8. doi: 10.1017/S0029665116002986

PubMed Abstract | CrossRef Full Text | Google Scholar

86. Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech Ageing Dev. (1990) 55:69–87. doi: 10.1016/0047-6374(90)90107-Q

PubMed Abstract | CrossRef Full Text | Google Scholar

87. Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity. (2016) 24:1874–83. doi: 10.1002/oby.21581

CrossRef Full Text | Google Scholar

88. Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes. (2011) 35:714–27. doi: 10.1038/ijo.2010.171

PubMed Abstract | CrossRef Full Text | Google Scholar

89. Higashida K, Fujimoto E, Higuchi M, Terada S. Effects of alternate-day fasting on high-fat diet-induced insulin resistance in rat skeletal muscle. Life Sci. (2013) 93:208–13. doi: 10.1016/j.lfs.2013.06.007

PubMed Abstract | CrossRef Full Text | Google Scholar

90. McNeil J, Mamlouk MM, Duval K, Schwartz A, Nardo Junior N, Doucet E. Alterations in metabolic profile occur in normal-weight and obese men during the Ramadan fast despite no changes in anthropometry. J Obes. (2014) 2014:482547. doi: 10.1155/2014/482547

PubMed Abstract | CrossRef Full Text | Google Scholar

91. Sadeghirad B, Motaghipisheh S, Kolahdooz F, Zahedi MJ, Haghdoost AA. Islamic fasting and weight loss: a systematic review and meta-analysis. Public Health Nutr. (2014) 17:396–406. doi: 10.1017/S1368980012005046

PubMed Abstract | CrossRef Full Text | Google Scholar

92. Baumeier C, Kaiser D, Heeren J, Scheja L, John C, Weise C, et al. Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice. Biochim Biophys Acta. (2015) 1851:566–76. doi: 10.1016/j.bbalip.2015.01.013

PubMed Abstract | CrossRef Full Text | Google Scholar

93. Soeters MR, Lammers NM, Dubbelhuis PF, Ackermans M, Jonkers-Schuitema CF, Fliers E, et al. Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. Am J Clin Nutr. (2009) 90:1244–51. doi: 10.3945/ajcn.2008.27327

CrossRef Full Text | Google Scholar

94. Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, et al. Timerestricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. (2012) 15:848–60. doi: 10.1016/j.cmet.2012.04.019

PubMed Abstract | CrossRef Full Text | Google Scholar

95. Chaix A, Zarrinpar A, Miu P, Panda S. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. (2014) 20:991–1005. doi: 10.1016/j.cmet.2014.11.001

PubMed Abstract | CrossRef Full Text | Google Scholar

96. Chowdhury EA, Richardson JD, Tsintzas K, Thompson D, Betts JA. Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults. Int J Obes. (2016) 40:305–11. doi: 10.1038/ijo.2015.154

PubMed Abstract | CrossRef Full Text | Google Scholar

97. Moro T, Tinsley G, Bianco A, Marcolin G, Pacelli QF, Battaglia G, et al. Effects of eight weeks of time-restricted feeding [16/8] on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. (2016) 14:290. doi: 10.1186/s12967-016-1044-0

CrossRef Full Text

98. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early timerestricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. (2018) 27:1212–21.e1213. doi: 10.1016/j.cmet.2018.04.010

PubMed Abstract | CrossRef Full Text | Google Scholar

99. Kul S, Savas E, €Ozt€urk ZA, Karada_g G. Does Ramadan fasting alter body weight and blood lipids and fasting blood glucose in a healthy population? A metaanalysis. J Relig Health. (2014) 53:929–42. doi: 10.1007/s10943-013-9687-0

CrossRef Full Text | Google Scholar

100. Liu H, Javaheri A, Godar RJ, Murphy J, Ma X, Rohatgi N, et al. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagylysosome pathway. Autophagy. (2017) 13:1952–68. doi: 10.1080/15548627.2017.1368596

PubMed Abstract | CrossRef Full Text | Google Scholar

101. Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Varady KA. Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans. Obesity. (2013) 21:1370–9. doi: 10.1002/oby.20353

PubMed Abstract | CrossRef Full Text | Google Scholar

102. Greenway FL. Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes. (2015) 39:1188e96. doi: 10.1038/ijo.2015.59

PubMed Abstract | CrossRef Full Text | Google Scholar

103. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. (2007) 86:7e13. doi: 10.1093/ajcn/86.1.7

PubMed Abstract | CrossRef Full Text | Google Scholar

104. Klempel MC, Kroeger CM, Varady KA. Alternate day fasting [ADF] with a high-fat diet produces similar weight loss and cardioprotection as ADF with a low-fat diet. Metabolism. (2013) 62:137e43. doi: 10.1016/j.metabol.2012.07.002

CrossRef Full Text | Google Scholar

105. Harris L, McGarty A, Hutchison L, Ells L, Hankey C. Short-term intermittent energy restriction interventions for weight management: a systematic review and meta-analysis. Obes Rev. (2017) 19:1–13. doi: 10.1111/obr.12593

PubMed Abstract | CrossRef Full Text | Google Scholar

106. Al-Hourani HM, Atoum MF. Body composition, nutrient intake and physical activity patterns in young women during Ramadan. Singapore Med J. (2007) 48:906–10.

PubMed Abstract | Google Scholar

107. Hajek P, Myers K, Dhanji AR, West O, McRobbie H. Weight change during and after Ramadan fasting. J Public Health. (2012) 34:377–81. doi: 10.1093/pubmed/fdr087

PubMed Abstract | CrossRef Full Text | Google Scholar

108. Yucel A, Degirmenci B, Acar M, Albayrak R, Haktanir A. The effect of fasting month of Ramadan on the abdominal fat distribution: assessment by computed tomography. Tohoku J Exp Med. (2004) 204:179–87. doi: 10.1620/tjem.204.179

PubMed Abstract | CrossRef Full Text | Google Scholar

109. Lamri-Senhadji MY, El Kebir B, Belleville J, Bouchenak M. Assessment of dietary consumption and time-course of changes in serum lipids and lipoproteins before, during and after Ramadan in young Algerian adults. Singapore Med J. (2009) 50:288–94.

PubMed Abstract | Google Scholar

110. Fahrial Syam A, Suryani Sobur C, Abdullah M, Makmun D. Ramadan fasting decreases body fat but not protein mass. Int J Endocrinol Metab. (2016) 14:e29687. doi: 10.5812/ijem.29687

PubMed Abstract | CrossRef Full Text | Google Scholar

111. Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. (2017) 9:eaai8700. doi: 10.1126/scitranslmed.aai8700

PubMed Abstract | CrossRef Full Text | Google Scholar

112. Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab. (2014) 25:42–52. doi: 10.1016/j.tem.2013.09.002

CrossRef Full Text | Google Scholar

113. Lu Z, Die J, Wu G, Shen J, Collins R, Chen W, et al. Fasting selectively blocks development of acute lymphoblastic leukaemia via leptin-receptor upregulation. Nat Med. (2017) 23:79–90. doi: 10.1038/nm.4252

PubMed Abstract | CrossRef Full Text | Google Scholar

114. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci USA. (2008) 105:8215–20. doi: 10.1073/pnas.0708100105

PubMed Abstract | CrossRef Full Text | Google Scholar

115. Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer. (2018) 18:707–19. doi: 10.1038/s41568-018-0061-0

PubMed Abstract | CrossRef Full Text | Google Scholar

116. Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, et al. Metabolic coupling and the Reverse Warburg Effect in cancer: implications for novel biomarker and anticancer agent development. Semin Oncol. (2017) 44:198–203. doi: 10.1053/j.seminoncol.2017.10.004

PubMed Abstract | CrossRef Full Text | Google Scholar

117. Nwosu ZC, Ebert MP, Dooley S, Meyer C. Caveolin-1 in the regulation of cell metabolism: a cancer perspective. Mol Cancer. (2016) 15:71. doi: 10.1186/s12943-016-0558-7

PubMed Abstract | CrossRef Full Text | Google Scholar

118. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. (2009) 324:1029–33. doi: 10.1126/science.1160809

PubMed Abstract | CrossRef Full Text | Google Scholar

119. Bovenzi CD, Hamilton J, Tassone P, Johnson J, Cognetti DM, Luginbuhl A, et al. Prognostic indications of elevated MCT4 and CD147 across cancer types: a meta-analysis. BioMed Res Int. (2015) 2015:242437. doi: 10.1155/2015/242437

PubMed Abstract | CrossRef Full Text | Google Scholar

120. Kalaany NY, Sabatini DM. Prognostic indications of elevated MCT4 and CD147 across cancer types: tumours with PI3K activation are resistant to dietary restriction. Nature. (2009) 458:725–31. doi: 10.1038/nature07782

CrossRef Full Text | Google Scholar

121. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. (2020) 583:620–4. doi: 10.1038/s41586-020-2502-7

PubMed Abstract | CrossRef Full Text | Google Scholar

122. Lis CG, Gupta D, Lammersfeld CA, Markman M, Vashi PG. Role of nutritional status in predicting quality of life outcomes in cancer—A systematic review of the epidemiological literature. Nutr J. (2012) 11:27. doi: 10.1186/1475-2891-11-27

PubMed Abstract | CrossRef Full Text | Google Scholar

123. Sukkar SG, Giacosa A, Frascio F. Clinical validation of bioelectrical impedance [BIA] in malnourished cancer patients. RINPE. (1993) 11:78–88.

124. Grundmann O, Yoon S, Williams J. The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review. Eur J Clin Nutr. (2015) 69:1290–7. doi: 10.1038/ejcn.2015.126

PubMed Abstract | CrossRef Full Text | Google Scholar

 

Creatine

Creatine

New in the world of research

Creatine has been proven to be a valuable supplement when it comes to increasing muscle and recovery, but new research may conclude possible cognitive benefits. More research has come out regarding the protective benefits of creatine monohydrate and the brain. Possible protective benefits include protective properties for neurodegenerative disease, amyotrophic lateral sclerosis, muscular dystrophy, Huntington’s disease, multiple sclerosis, Parkinson’s, overall mental health, depression, anxiety and post-traumatic stress disorder, 

We’ve known for some time about the benefits of creatine and increasing muscle mass, but….It wasn’t until recently did we learn about the benefits for the brain and heart. 95% of creatine storage is in the muscle and the remaining 5% is stored in the heart and brain. Supplementing with creatine significantly benefits optimal healthy creatine levels. Creatine possesses anti-oxidant, anti-apoptotic, and anti-excitotoxic properties. Clinical research on neurodegenerative illnesses has shown that Creatine supplementation results in less effective outcomes. 

 

Benefits

One of the most well studied supplements in health and fitness for increasing muscle mass and energy output. However, there are other forms of creatine as well. Data shows that Creatine monohydrate is the best form on creatine. The benefits of creatine do not differ in other alkaline forms or buffered creatine. We recommend any creatine monohydrate. 

Our Recommendations

Recent publications shown healthy brain creatine levels may improve mitochondrial function and improve oxidative stress, which may be relevant treatments for neurodegenerative diseases , including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS).

SOURCES:

Chang H, Leem YH. The potential role of creatine supplementation in neurodegenerative diseases. Phys Act Nutr. 2023 Dec;27(4):48-54. doi: 10.20463/pan.2023.0037. Epub 2023 Dec 31. PMID: 38297476; PMCID: PMC10844727.

Antonio J, Candow DG, Forbes SC, Gualano B, Jagim AR, Kreider RB, Rawson ES, Smith-Ryan AE, VanDusseldorp TA, Willoughby DS, Ziegenfuss TN. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? J Int Soc Sports Nutr. 2021 Feb 8;18(1):13. doi: 10.1186/s12970-021-00412-w. PMID: 33557850; PMCID: PMC7871530.

Wax B, Kerksick CM, Jagim AR, Mayo JJ, Lyons BC, Kreider RB. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients. 2021 Jun 2;13(6):1915. doi: 10.3390/nu13061915. PMID: 34199588; PMCID: PMC8228369.

Wu SH, Chen KL, Hsu C, Chen HC, Chen JY, Yu SY, Shiu YJ. Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021. Nutrients. 2022 Mar 16;14(6):1255. doi: 10.3390/nu14061255. PMID: 35334912; PMCID: PMC8949037.

Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, Rawson ES, Roy BD, Prokopidis K, Giannos P, Candow DG. Effects of Creatine Supplementation on Brain Function and Health. Nutrients. 2022 Feb 22;14(5):921. doi: 10.3390/nu14050921. PMID: 35267907; PMCID: PMC8912287.

Forbes SC, Candow DG, Neto JHF, Kennedy MD, Forbes JL, Machado M, Bustillo E, Gomez-Lopez J, Zapata A, Antonio J. Creatine supplementation and endurance performance: surges and sprints to win the race. J Int Soc Sports Nutr. 2023 Dec;20(1):2204071. doi: 10.1080/15502783.2023.2204071. PMID: 37096381; PMCID: PMC10132248.

Stares A, Bains M. The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials. J Geriatr Phys Ther. 2020 Apr/Jun;43(2):99-112. doi: 10.1519/JPT.0000000000000222. PMID: 30762623.

Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14:18. doi: 10.1186/s12970-017-0173-z. PMID: 28615996; PMCID: PMC5469049.

 

Keto and Muscle

Is Keto the way to go?

Well, this would depend on your health goal and foods you like. The data proves that weight loss will occur regardless if you eat a low carbohydrate diet or a low fat diet. Reducing calories from a single source of macronutrients will aid in weight loss. It’s important to consider the types of foods you enjoy and if they fit into the higher carbohydrates – low fat or higher fat – low carbohydrate model. The foods you tend to enjoy will help you stay focused on your diet. For example, if you like eggs, meats, dairy, nuts and seeds, then it would be wise for you to go low carbohydrate. However, if you like oatmeal, rice, potatoes, and pasta, then it would be wise to go low fat -higher carbohydrates. The best diet is the one you’ll end up sticking with. 

What is Keto? Keto is short for ketogenesis, which is the process of creating ketone bodies to serve as a fuel source if glucose levels are too low. It should be advised that ketone synthesis reaction yields HMG CoA, which is a precursor of cholesterol. This concludes higher elevations of serum cholesterol as a result of being on a low carb diet. The theory behind keto is by limited glucose by means of carbohydrates, then the body will processes fat to sustain energy balance. 

How does our body burn fat? 
    In order for our body to obtain energy from fat, our body will break down triglycerides into fatty acids and glycerol. This process is known as lipolysis, and fatty acids are oxidized by B-oxidation into acetyl CoA. Acetyl CoA is used by the Krebs cycle to generate energy. Triglyceride molecule yield more energy than carbohydrates and are an important source of energy. Organs such as the brain require glucose in order to function. However, the body can use ketones as an alternative energy source to keep the brain functioning when glucose is limited. If ketones aren’t used, then they can be broken down into CO2 and acetone. Acetone is removed by means of exhalation, which may cause the breath of an individual to have sweet breath like alcohol. The carbon dioxide produced can acidify the blood, and could lead to diabetic ketoacidosis. 

The problem is carbohydrates and Fat together

When glucose levels are complete, acetyl CoA generated by glycolysis is converted into fatty acids, triglycerides, cholesterol, steroids, and bile salts. Lipogenesis creates fat from acetyl CoA generated from the Krebs cycle an place in the cytoplasm of adipocytes (Fat cells)  and hepatocytes. (Liver cells)  It would be recommended to not consume too many calories from fat and carbohydrates at the same time. The theory behind is both contribute to fuel sources for the body, and when glucose is in abundance, then the body will store the excess as fat. 

Issues with Keto Diet? 

Data has shown favorable biochemical and physiological effects during weight loss periods. However, there’s been studies to record endothelial function, C-reactive Protein and fat during maintenance level.  High fat diets, like the one Keto promotes has been shown to increase low-density lipoprotein, increase visceral obesity and metabolic syndrome proving the long term effects may not be favorable. However, saturated fat might be the source of the problem compared to unsaturated fat. There’s also a problem for men due to lower resting testosterone and greater cortisol levels post physical activity. A low carbohydrate diet over a long period of time may cause greater affects on the endocrine system. What about for women? In a randomize cross over study, women had reduced exercise performance in activities on a keto diet. Ketogenesis is a process to supply glucose to the organs that require glucose, and limited studies have shown the long term effects of being in this state. Data suggest an increased risk for metabolic syndrome. 

What's best for performance

This also depends on the type of physique or style of training you prefer. If you want a smaller, lean physique then eating a low carbohydrate diet and higher fat might work better for you. A ketogenetic style diet will limit glycogen in the muscle making the muscle look flatter.  If you enjoy moderate to low resistance training, jogging, and walking, then lower carbohydrates may work better for you depending on your level of performance. A low-carb diet might not be suited for a strength athlete or a long distance runners. The primary reason for this logic is due to the metabolic pathway to process energy by means of ATP for use by the body to power physiological processes. Glucose is the body’s most readily available source of energy. After digestion, the body breaks down polysaccharides into monosaccharides, which are transported from the small intestines to the circulatory system or stores the excess as glycogen stored in the muscle cell. Since glycogen is the primary energy source for easily expenditure, it’s valuable during exercise and weight training. Building muscle in a ketogenetic state is counterproductive. Eating carbohydrates is valuable when considering carbohydrates with a low glycemic index. A glycemic index is a metric used to determine the rate of breakdown. Simple sugar is very high whereas oatmeal is low. 

The Break Down (Science)

Key organs require glucose to function including the brain, and therefore it’s essential to maintain a minimum blood glucose level. The breakdown of carbohydrates from whole food sources packet with fiber and phytonutrients is preferred, and carbohydrate metabolism is an extensive process called Glycolysis. glycolysis is rather complex exchange of phosphates molecules referred to as the Krebs cycle to produce 4 ATP molecules. Carbohydrate metabolism involves multiple processes such as glycolysis, Krebs Cycle, and the electron transport chain. 

During times of starvation or low carbohydrate diets, the liver is able to synthesize new glucose from pyruvate, lactate, glycerol, or amino acids alanine or glutamine. This process is known as Gluconeogenesis. 

How does the body breakdown fat? Lipid metabolism begins in the intestine where triglycerides are broken down into fatty acids and monoglyceride molecule by means of pancreatic lipases. 

Final Take

Data shows, at least for short term, keto diets are safe and effective for losing weight. However, a reduction of calories from all macronutrients is the preferred method for weight loss. Some data concludes an adherence to a keto-diet proving the diet to be less effective the longer someone stays on the diet. To take advantages of both lipid and carbohydrates metabolism, carbohydrate and fat cycling would be the best approach. Carb- cycling is the method for alternating between high carb – low fat either on a weekly or monthly cycle. Ketogenic diets may help aid in weight loss because it’s easier for people to avoid one macronutrient than focus on reducing calories from all sources. However, data proves that weight loss occurs at the same rate regardless of high fat-low carb or high carb- low fat. Similar to the source of carbohydrates, the source of fat may play a crucial rule in the prevention of cardiovascular disease. 

Sources

Miller M, Beach V, Sorkin JD, Mangano C, Dobmeier C, Novacic D, Rhyne J, Vogel RA. Comparative effects of three popular diets on lipids, endothelial function, and C-reactive protein during weight maintenance. J Am Diet Assoc. 2009 Apr;109(4):713-7. doi: 10.1016/j.jada.2008.12.023. PMID: 19328268; PMCID: PMC2693202.

Ornish D. Comparison of diets for weight loss and heart disease risk reduction. JAMA. 2005 Apr 6;293(13):1589-90; author reply 1590-1. doi: 10.1001/jama.293.13.1589. PMID: 15811973.

Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS Jr, Brehm BJ, Bucher HC. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006 Feb 13;166(3):285-93. doi: 10.1001/archinte.166.3.285. Erratum in: Arch Intern Med. 2006 Apr 24;166(8):932. PMID: 16476868.

Skytte MJ, Samkani A, Petersen AD, Thomsen MN, Astrup A, Chabanova E, Frystyk J, Holst JJ, Thomsen HS, Madsbad S, Larsen TM, Haugaard SB, Krarup T. A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial. Diabetologia. 2019 Nov;62(11):2066-2078. doi: 10.1007/s00125-019-4956-4. Epub 2019 Jul 23. PMID: 31338545.

Tay J, Luscombe-Marsh ND, Thompson CH, Noakes M, Buckley JD, Wittert GA, Yancy WS Jr, Brinkworth GD. Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial. Am J Clin Nutr. 2015 Oct;102(4):780-90. doi: 10.3945/ajcn.115.112581. Epub 2015 Jul 29. PMID: 26224300.

Wachsmuth NB, Aberer F, Haupt S, Schierbauer JR, Zimmer RT, Eckstein ML, Zunner B, Schmidt W, Niedrist T, Sourij H, Moser O. The Impact of a High-Carbohydrate/Low Fat vs. Low-Carbohydrate Diet on Performance and Body Composition in Physically Active Adults: A Cross-Over Controlled Trial. Nutrients. 2022 Jan 18;14(3):423. doi: 10.3390/nu14030423. PMID: 35276780; PMCID: PMC8838503.

Wachsmuth NB, Aberer F, Haupt S, Schierbauer JR, Zimmer RT, Eckstein ML, Zunner B, Schmidt W, Niedrist T, Sourij H, Moser O. The Impact of a High-Carbohydrate/Low Fat vs. Low-Carbohydrate Diet on Performance and Body Composition in Physically Active Adults: A Cross-Over Controlled Trial. Nutrients. 2022 Jan 18;14(3):423. doi: 10.3390/nu14030423. PMID: 35276780; PMCID: PMC8838503.

Burke LM, Whitfield J, Heikura IA, Ross MLR, Tee N, Forbes SF, Hall R, McKay AKA, Wallett AM, Sharma AP. Adaptation to a low carbohydrate high fat diet is rapid but impairs endurance exercise metabolism and performance despite enhanced glycogen availability. J Physiol. 2021 Feb;599(3):771-790. doi: 10.1113/JP280221. Epub 2020 Aug 19. PMID: 32697366; PMCID: PMC7891450.

Whittaker J, Harris M. Low-carbohydrate diets and men’s cortisol and testosterone: Systematic review and meta-analysis. Nutr Health. 2022 Dec;28(4):543-554. doi: 10.1177/02601060221083079. Epub 2022 Mar 7. Erratum in: Nutr Health. 2022 Dec;28(4):783. PMID: 35254136; PMCID: PMC9716400.

Wroble KA, Trott MN, Schweitzer GG, Rahman RS, Kelly PV, Weiss EP. Low-carbohydrate, ketogenic diet impairs anaerobic exercise performance in exercise-trained women and men: a randomized-sequence crossover trial. J Sports Med Phys Fitness. 2019 Apr;59(4):600-607. doi: 10.23736/S0022-4707.18.08318-4. Epub 2018 Apr 4. PMID: 29619799.

Zdzieblik D, Friesenborg H, Gollhofer A, König D. A high carbohydrate diet with a low glycaemic index improves training effects in male endurance athletes. Int J Food Sci Nutr. 2022 Nov;73(7):965-972. doi: 10.1080/09637486.2022.2091525. Epub 2022 Jun 26. PMID: 35758204.

Thom G, Lean M. Is There an Optimal Diet for Weight Management and Metabolic Health? Gastroenterology. 2017 May;152(7):1739-1751. doi: 10.1053/j.gastro.2017.01.056. Epub 2017 Feb 15. PMID: 28214525.

White AM, Johnston CS, Swan PD, Tjonn SL, Sears B. Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: a pilot study. J Am Diet Assoc. 2007 Oct;107(10):1792-6. doi: 10.1016/j.jada.2007.07.009. PMID: 17904939.

Ong PJ, Dean TS, Hayward CS, Della Monica PL, Sanders TA, Collins P. Effect of fat and carbohydrate consumption on endothelial function. Lancet. 1999 Dec 18-25;354(9196):2134. doi: 10.1016/s0140-6736(99)03374-7. PMID: 10609824.

Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WS Jr, Brehm BJ, Bucher HC. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006 Feb 13;166(3):285-93. doi: 10.1001/archinte.166.3.285. Erratum in: Arch Intern Med. 2006 Apr 24;166(8):932. PMID: 16476868.

Sheikh, Mujeeb MD; Chahal, Mangeet MD; Rock-Willoughby, Jayme DO; Grubb, Blair P. MD. Carbohydrate-Restricted Diet and Acute Coronary Syndrome: A Case Report and Review of This Conflicting and Yet Unknown Association. American Journal of Therapeutics 21(2):p e41-e44, March/April 2014. | DOI: 10.1097/MJT.0b013e318235f1df

Anderson JW, Ward K. High-carbohydrate, high-fiber diets for insulin-treated men with diabetes mellitus. Am J Clin Nutr. 1979 Nov;32(11):2312-21. doi: 10.1093/ajcn/32.11.2312. PMID: 495550.

Parry SA, Woods RM, Hodson L, Hulston CJ. A Single Day of Excessive Dietary Fat Intake Reduces Whole-Body Insulin Sensitivity: The Metabolic Consequence of Binge Eating. Nutrients. 2017 Jul 29;9(8):818. doi: 10.3390/nu9080818. PMID: 28758920; PMCID: PMC5579612.

L-theanine

L- Theanine

Why you should consider taking L- Theanine

L- theanine is the primary amino acid in tea leaves, and known for it’s calming affect. Although recent data shows it may also play an important role in immunity and prevention. Numerous cell and animal studies have proven that theanine plays an important role in reducing inflammation. Additionally, theanine may also help with nerve damage, gut health and prevention of tumors by regulating glutathione synthesis and the secretion of cytokine and neurotransmitters. 

Theanine may also improve cognitive performance and enhance working memory. In a study from 2021, researchers found a single dose of theanine reduced the reaction to attention to tasks, and increased the number of correct answers while decreasing the number of omission errors in working memory tasks. Another randomized, placebo controlled, crossover, and double-blind trial shown significant improvements in overall mental health while reducing stress. Overall, depression, anxiety and sleep scores all decreased and cognitive function scores improved of 4 weeks of 200mg taken daily. 

Citations:

Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. 2021 Apr;24(4):333-341. doi: 10.1089/jmf.2020.4803. Epub 2021 Mar 22. PMID: 33751906; PMCID: PMC8080935.

Chen S, Kang J, Zhu H, Wang K, Han Z, Wang L, Liu J, Wu Y, He P, Tu Y, Li B. L-Theanine and Immunity: A Review. Molecules. 2023 May 1;28(9):3846. doi: 10.3390/molecules28093846. PMID: 37175254; PMCID: PMC10179891.

Dassanayake TL, Kahathuduwa CN, Weerasinghe VS. L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study. Nutr Neurosci. 2022 Apr;25(4):698-708. doi: 10.1080/1028415X.2020.1804098. Epub 2020 Aug 11. PMID: 32777998.

Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, Oliveira Santos H. Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia. Pharmacol Res. 2019 Sep;147:104395. doi: 10.1016/j.phrs.2019.104395. Epub 2019 Aug 11. PMID: 31412272.

Williams JL, Everett JM, D’Cunha NM, Sergi D, Georgousopoulou EN, Keegan RJ, McKune AJ, Mellor DD, Anstice N, Naumovski N. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020 Mar;75(1):12-23. doi: 10.1007/s11130-019-00771-5. PMID: 31758301.

Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.