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Nicotinamide mononucleotide (NMN)

They Key to Anti-aging

As we get older, we lose the ability to produce certain molecules that help the body stay youthful. As we age, we experience greater amounts of inflammation, DNA damage, and slower metabolism. Some longevity experts claim aging is disease we all experience. However, anti-aging supplements may not actually prevent aging as much help aid in graceful aging. Nicotinaminde Mononucleotide (NMN) is a precursor for nicotinamide adenine dinucleotide. (NAD) Our bodies utilize NAD for variety of functions like energy metabolism, DNA repair, gene expression and cellular stress responses.  Throughout our lives, we lose concentrations of NAD, and supplementing with NMN could significantly improve many biomarkers and aid in longevity.

Additional benefits include:

  • It may increase longevity
  • It may have protective effects on the brain
  • It may help reduce heart disease risk.
  • It may protect against cancer.
  • It may help aging muscles

Put NMN To the test

How does NMN work when supplementation is put to the test for athletic performance and aging? In animal studies, NMN supplementation increase nicotinamide adenine dinucleotide (NAD) concentrations and improves health span and lifespan.  A randomized clinical trial included 80 middle-aged health adults for 60-days taking a once daily oral dosing of 300,600, and 900mg. 

What were the results?

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NMN Results

Randomize control trial of 80 middle aged adults taking NMN for 60 days saw significant improvements in the slowing of aging as well as athletic performance. 

  • Greater blood NAD levels
  • Better endurance
  • May increase muscle recovery
  • Improvements in blood glucose levels
  • Reduction in blood biological age
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Optimal dosage appears to be around a 600mg daily intake. However, safe and effective dosage drawn from the literature appears to be safe up to 1,000mg. Although, long term studies are currently in review. 

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References

  • Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188.
  • arshani Nadeeshani, Jinyao Li, Tianlei Ying, Baohong Zhang, Jun Lu,
    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns, Journal of Advanced Research, Volume 37, 2022, Pages 267-278,
    ISSN 2090-1232, https://doi.org/10.1016/j.jare.2021.08.003.
    (https://www.sciencedirect.com/science/article/pii/S2090123221001491)
  • A. Kumar, P. Chanana,
    Chapter Six – Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target,
    Editor(s): Gerald Litwack, Vitamins and Hormones, Academic Press, Volume 103, 2017, Pages 147-167, ISSN 0083-6729, ISBN 9780128119143,
    https://doi.org/10.1016/bs.vh.2016.09.004.
    (https://www.sciencedirect.com/science/article/pii/S0083672916300462)
  • Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608.
  • Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh, Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men, Endocrine Journal, 2024, Volume 71, Issue 2, Pages 153-169, Released on J-STAGE February 28, 2024, Advance online publication January 06, 2024, Online ISSN 1348-4540, Print ISSN 0918-8959, https://doi.org/10.1507/endocrj.EJ23-0431, https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0431/_article/-char/en, Abstract: