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What is Science Based Fitness?

Your free- source of information, news, and deep dive into the latest science in the world or fitness and health. We dive deep into the literature and debunk a lot of fake claims. Also, providing helpful tips and workouts to improve your health and quality of life. 

Truth About Cholesterol

The Truth

About Cholesterol

Is high cholesterol bad?

Take the first step to your healthiest self.

You might’ve heard some experts claim high cholesterol isn’t a risk factor for many diseases or health risk. However, what about high levels of low density -lipoproteins? (LDL) 

What is cholesterol? 
Cholesterol is a waxy substance found in your blood, and it’s required for many biological processes such as building healthy cells and hormone release. Cholesterol is carried throughout the blood by transport proteins called lipoprotein. However, there are different types of transport proteins. A lipid profile also measures triglycerides, which is commonly known as a type of fat in the blood. 

Low-density Lipoprotein – Known as bad cholesterol, and cholesterol particles builds up in the walls of your arteries making them hard and narrow. 

High-density Lipoprotein – Known as good cholesterol, and can pick up excess cholesterol and take back to your liver. 

The cause of high LDL

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It was thought that dietary cholesterol may raise blood cholesterol. So, many people with high cholesterol were told avoid high cholesterol foods. This is no longer the case as studies confirm high dietary intake isn’t directly associated with high LDL. Although, foods high in saturated fat will impact blood LDL levels. As trans or saturated fat is metabolized, the liver can produce excess cholesterol. It’s best to avoid or reduce foods high in saturated fat if you already have higher than optimal LDL. Other risk factors that increase high LDL are:

Prevention

Take the first step to your healthiest self.

Heart healthy lifestyle changes are important and can lower your risk of heart disease, stroke, and cancer. 

Low salt diet with plenty of fruits, vegetables, and whole grains
100%
Lose weight and increase exercise
100%
Limit animal fats and replace with omega 3 fatty acids.
100%
Drink alcohol in moderation and quit smoking
100%

Review

Although some still claim high LDL cholesterol is not a risk factor for many heart related diseases, there’s still a lot of support and evidence that proves high LDL is still a major risk factor. currently, high LDL is still the largest risk factor. Some experts claim people can die from heart disease regardless if their LDL cholesterol is within range. For many, “in range” is already too high of a benchmark. Also, many people are prescribed statins to lower their LDL. Although, damage to their blood vessels might have already occurred, and therefore, a statin cannot reverse some or all of the damage. Regardless of  beliefs, statins still increase lifespan for those with high cholesterol. No drug can out perform diet and exercise, or other lifestyle changes. Prevention is still key. 

References

and Citations

  • Lee Y, Siddiqui WJ. Cholesterol Levels. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542294/
  • Schoeneck M, Iggman D. The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1325-1338. doi: 10.1016/j.numecd.2020.12.032. Epub 2021 Jan 16. PMID: 33762150.
  • Ho HV, Sievenpiper JL, Zurbau A, Blanco Mejia S, Jovanovski E, Au-Yeung F, Jenkins AL, Vuksan V. The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 2016 Oct;116(8):1369-1382. doi: 10.1017/S000711451600341X. Epub 2016 Oct 11. PMID: 27724985.
  • Wadhera RK, Steen DL, Khan I, Giugliano RP, Foody JM. A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. J Clin Lipidol. 2016 May-Jun;10(3):472-89. doi: 10.1016/j.jacl.2015.11.010. Epub 2015 Nov 25. PMID: 27206934.
  • Virani SS, Aspry K, Dixon DL, Ferdinand KC, Heidenreich PA, Jackson EJ, Jacobson TA, McAlister JL, Neff DR, Gulati M, Ballantyne CM. The importance of low-density lipoprotein cholesterol measurement and control as performance measures: A joint clinical perspective from the National Lipid Association and the American Society for Preventive Cardiology. Am J Prev Cardiol. 2023 Feb 27;13:100472. doi: 10.1016/j.ajpc.2023.100472. PMID: 36970638; PMCID: PMC10037190.
  • Feingold, K. R. (2024, February 12). Cholesterol lowering drugs. Endotext [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK395573/ 
     

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Best supplement for musle

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nmn

Antiaging

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Nicotinamide mononucleotide (NMN)

Nicotinamide mononucleotide (NMN)

They Key to Anti-aging

As we get older, we lose the ability to produce certain molecules that help the body stay youthful. As we age, we experience greater amounts of inflammation, DNA damage, and slower metabolism. Some longevity experts claim aging is disease we all experience. However, anti-aging supplements may not actually prevent aging as much help aid in graceful aging. Nicotinaminde Mononucleotide (NMN) is a precursor for nicotinamide adenine dinucleotide. (NAD) Our bodies utilize NAD for variety of functions like energy metabolism, DNA repair, gene expression and cellular stress responses.  Throughout our lives, we lose concentrations of NAD, and supplementing with NMN could significantly improve many biomarkers and aid in longevity.

Additional benefits include:

Put NMN To the test

How does NMN work when supplementation is put to the test for athletic performance and aging? In animal studies, NMN supplementation increase nicotinamide adenine dinucleotide (NAD) concentrations and improves health span and lifespan.  A randomized clinical trial included 80 middle-aged health adults for 60-days taking a once daily oral dosing of 300,600, and 900mg. 

What were the results?

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NMN Results

Randomize control trial of 80 middle aged adults taking NMN for 60 days saw significant improvements in the slowing of aging as well as athletic performance. 

Optimal dosage appears to be around a 600mg daily intake. However, safe and effective dosage drawn from the literature appears to be safe up to 1,000mg. Although, long term studies are currently in review. 

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References

  • Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188.
  • arshani Nadeeshani, Jinyao Li, Tianlei Ying, Baohong Zhang, Jun Lu,
    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns, Journal of Advanced Research, Volume 37, 2022, Pages 267-278,
    ISSN 2090-1232, https://doi.org/10.1016/j.jare.2021.08.003.
    (https://www.sciencedirect.com/science/article/pii/S2090123221001491)
  • A. Kumar, P. Chanana,
    Chapter Six – Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target,
    Editor(s): Gerald Litwack, Vitamins and Hormones, Academic Press, Volume 103, 2017, Pages 147-167, ISSN 0083-6729, ISBN 9780128119143,
    https://doi.org/10.1016/bs.vh.2016.09.004.
    (https://www.sciencedirect.com/science/article/pii/S0083672916300462)
  • Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608.
  • Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh, Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men, Endocrine Journal, 2024, Volume 71, Issue 2, Pages 153-169, Released on J-STAGE February 28, 2024, Advance online publication January 06, 2024, Online ISSN 1348-4540, Print ISSN 0918-8959, https://doi.org/10.1507/endocrj.EJ23-0431, https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0431/_article/-char/en, Abstract:

Taurine

Taurine

A secret supplement for longevity and health?

Taurine

May help prevent cardiovascular disease, increase lifespan, and more

Taurine is an amino acid that occurs naturally in the body and is found in many foods. It’s considered semi-essential or conditionally essential because it’s derived from cysteine like other amino acids but lacks a carboxyl group. Instead, it contains a sulfide group and can be called an amino sulfonic acid.

Taurine helps with bodily functions, including those of the digestive, cardiovascular, skeletal, muscular, and nervous systems. It also works as a neurotransmitter in the brain and is used for energy production. Taurine has antioxidant and anti-inflammatory properties that may enhance insulin sensitivity, which could reduce the risk of type 2 diabetes or improve blood sugar management
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HEALTH

Improve Health

Introduction to chronic inflammation

Recent studies show chronic inflammation may be the greatest contribution to disease, or a cornerstone for the development of cardiovascular disease. Other major heath factors include pollution, environmental stresses, drugs, excess food consumption and obesity.  Obesity is a major contribution to negative health outcomes. Managing a health body mass is crucial in over health. Taurine may help heart health and enhance endothelial function, which may significantly reduce the risk of atherosclerosis and cardiovascular events.  Taurine accounts for 50% of the total free amino acids in the heart, and it’s been shown to enhance cardiac contractility and improve heart function. 

Taurine is abundant in skeletal muscle, but the largest benefit of taurine is glucose and lipid regulation, energy metabolism, anti-inflammatory modulation and antioxidant action. Taurine may also aid in athletic performance such as muscle repair and cardiovascular improvements.

Taurine

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References

Citations 

  • Lin Guan, Peng Miao, The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials, European Journal of Pharmacology, Volume 885, 2020, 173533,ISSN 0014-2999,
  • Santulli G, Kansakar U, Varzideh F, Mone P, Jankauskas SS, Lombardi A. Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients. 2023; 15(19):4236. https://doi.org/10.3390/nu15194236
  • Ahmadian M, Roshan VD, Aslani E, Stannard SR. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure. Therapeutic Advances in Cardiovascular Disease. 2017;11(7):185-194. doi:10.1177/1753944717711138
  • Ahmadian, M., Dabidi Roshan, V., & Ashourpore, E. (2017). Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure. Journal of Dietary Supplements14(4), 422–432. https://doi.org/10.1080/19390211.2016.1267059
  • Kurtz, J. A., VanDusseldorp, T. A., Doyle, J. A., & Otis, J. S. (2021). Taurine in sports and exercise. Journal of the International Society of Sports Nutrition18(1). https://doi.org/10.1186/s12970-021-00438-0